Chronic Ethanol Exposure Closes the Door to Vitamin C in Pancreatic Acinar Cells
نویسندگان
چکیده
1 2 3 4 Alexander L. Ticho3 & Waddah A. Alrefai1,2,# 5 6 7 Jesse Brown VA Medical Center, Division of Gastroenterology & Hepatology, Department of 8 Medicine, Department of Physiology & Biophysics, University of Illinois at Chicago, Chicago, IL, 9 10 11 12 Grants support: 13 The research in the authors’ laboratory is supported by grants from the Department of Veterans 14 Affairs BX000152 (WAA) and the NIDDK/NIH DK71596 (WAA). 15 16 17 #Author to whom all correspondence including reprint requests should be addressed: 18 19 20 Waddah A. Alrefai., MD 21 Research Career Scientist 22 Jesse Brown VA Medical Center 23 Associate Professor 24 University of Illinois at Chicago 25 Jesse Brown VA Medical Center 26 Medical Research Service (600/151) 27 820 South Damen Avenue 28 Chicago, IL 60612 29 E-mail: [email protected] 30 Tel. (312) 569-7429 31 Fax (312) 569-8114 32 33
منابع مشابه
Chronic ethanol exposure closes the door to vitamin C in pancreatic acinar cells. Focus on "Uptake of ascorbic acid by pancreatic acinar cells is negatively impacted by chronic alcohol exposure".
PANCREATITIS IS AN INFLAMMATORY DISEASE that causes significant health care burden worldwide. Treatment of pancreatitis is severely limited by a lack of understanding of the molecular mechanisms underlying the pathophysiology (2). Recent evidence has implicated oxidative stress within pancreatic acinar cells (PACs) in the pathogenesis of this disease (8). Ascorbic acid (AA) is a crucial antioxi...
متن کاملUptake of ascorbic acid by pancreatic acinar cells is negatively impacted by chronic alcohol exposure.
Vitamin C (ascorbic acid, AA) is indispensable for normal metabolism of all mammalian cells including pancreatic acinar cells (PACs). PACs obtain AA from their surroundings via transport across the cell membrane. Chronic alcohol exposure negatively affects body AA homeostasis; it also inhibits uptake of other micronutrients into PACs, but its effect on AA uptake is not clear. We examined this i...
متن کاملChronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells
Thiamin (vitamin B1), a member of the water-soluble family of vitamins, is essential for normal cellular functions; its deficiency results in oxidative stress and mitochondrial dysfunction. Pancreatic acinar cells (PAC) obtain thiamin from the circulation using a specific carrier-mediated process mediated by both thiamin transporters -1 and -2 (THTR-1 and THTR-2; encoded by the SLC19A2 and SLC1...
متن کاملPanceratic Complications of Mustard Gas Exposure: A Study on Cadavers
Background: Sulfur mustard is one of the chemical warfare gases that has been known as a vesicant or blistering agents. It is a chemical alkylating compound agent that can be frequently absorbed through skin, respiratory system, genital tract, and ocular system. This study was done to pathologically analyze the microscopic pancreatic lesions in cadavers. Methods: This case series study was per...
متن کاملThiamin uptake by pancreatic acinar cells: effect of chronic alcohol feeding/exposure.
Thiamin is important for normal function of pancreatic acinar cells, but little is known about its mechanism of uptake and about the effect of chronic alcohol use on the process. We addressed these issues using freshly isolated rat primary and rat-derived cultured AR42J pancreatic acinar cells as models. Results showed thiamin uptake by both primary and cultured AR42J pancreatic acinar cells to...
متن کامل